Fig. 1.
Voxel-wise DBM Jacobian beta maps indicating significant ventricular differences between each cohort and age-matched controls (FDR corrected p-value < 0.05). From left to right: MCI vs CN, AD vs CN, bvFTD vs CN, PNFA vs CN and SV vs CN. Model: DBMVentricles ∼ 1 + Cohort + AGE + Sex + (1|ID) + (1|SITE). The figures show the significant beta values obtained for the categorical variable DX (i.e., bvFTD vs CN). Colormaps within the ventricles shows the degree of ventricle enlargement for each cohort compared to CN overlaid on the ADNI unbiased average brain template (warmer colors indicate regions with greater ventricle enlargement than regions with colder colors, varying from 1% larger to 10 times larger).