Table 1.
Demographic and clinical characteristics for all the cohorts. Values express Mean ± SD / Median [interquartile range]. P value level of significance: 0.05. Abbreviations: CN: cognitively normal controls; bvFTD: behavioral variant frontotemporal dementia; SV: semantic variant; PNFA: primary nonfluent aphasia; MCI: mild cognitive impairment; AD: Alzheimer’s dementia; MMSE: Mini-Mental Status Examination; MoCA: Montreal Cognitive Assessment; CDR-SB: Clinical Dementia Rating-Sum of Boxes.
| NIFD |
ADNI |
P | ||||||
|---|---|---|---|---|---|---|---|---|
| CN (N=129) | bvFTD (N=69) | SV (N=38) | PNFA (N=37) | CN (N=113) | MCI (N=218) | AD (N= 74) | ||
| Scans | 447 | 231 | 175 | 138 | 500 | 1037 | 222 | |
| N°Scans/Subject (mean) | 3.4 | 3.4 | 4.6 | 3.7 | 4.4 | 4.7 | 3 | 0.4 |
| Age (y) | 62±7 | 61±6 | 62±6 | 68±7 | 70±4 | 69±5 | 69±6 | <0.001 |
| Sex (male%) | 56 (43%) | 45 (65%) | 21 (55%) | 17 (46%) | 64 (57%) | 113 (52%) | 34 (46%) | 0.07 |
| Follow-up (y) | 1.3[0.6-3.4] | 1[0.5-1.4] | 1.2[1-16]] | 1.1[0.6-1.5] | 2[1.1-2.3] | 2[1.1-3] | 1[0.2-1.1] | <0.001 |
| MMSE | 30[29-30] | 25[22-27] | 26[22-28] | 27[21-28] | 29[29-30] | 28[27-29] | 24[21-25] | <0.001 |
| MoCA | 28[25-29] | 19[12-23] | 21[17-22] | 21[10-25] | 26[25-28] | 23[21-26] | 19[14-21] | <0.001 |
| CDR-SB | 0 | 6[4.5-8.5] | 3.5[2.5-5.5] | 2[1-3.5] | 0 | 1.5[1-2] | 4.5[3-5] | <0.001 |