Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 15;77:103869. doi: 10.1016/j.ebiom.2022.103869

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig 3 — Distribution of both reported and non-reported loss of function, and missense variants in all 13 studied NBIA genes. (a) depicts a correlation between the number of reported variants and a year of gene identification and association with an NBIA disorder. (b) shows a correlation between the number of variants that was adjusted with a factor for the gene size (number of amino acids of a gene x/average number of amino acids of all 13 NBIA genes) and the time period since the identification and association with an NBIA disorder (i.e. 2021 - the year of publication). Due to the multivariate testing, p-value of less than 0.01 was considered statistically significant (Spearman correlation coefficient, Bonferroni correction for 5 hypotheses). For each gene, a year of description and/or the size of the gene in kb is shown below (A, B).¹⁹^,²²^,34, 35, 36, 37, 38, 39, 40, 41, 42, 43 Data are expressed as whole numbers.

LoF, Loss of Function; NBIA, Neurodegeneration with Brain Iron accumulation; n, number.