Table 1.

Pharmacological profile of selective serotonin reuptake inhibitors (SSRIs) and vortioxetine [13]

	SERT inhibition	5HT2C antagonism	NET inhibition	DAT inhibition	σ1 agonist	M1 antagonism	NOS inhibition	H1-antagonist	5HT1A agonist	5HT1B partial agonist	5HT1D antagonist	5HT3 antagonist	5HT7 antagonist
Citalopram	+							+
Escitalopram	+
Fluoxetine	+	+	+ (only at very high doses)
Fluvoxamine	+				+
Paroxetine	+		+			+	+
Sertraline	+			+	+
Venlafaxine	+		+
Vortioxetine	+								+	+	+	+	+

SERT serotonin transporter, 5-HT 5-hydroxytryptamine, DAT dopamine transporter, H1 histamine 1 receptor, M1 muscarinic acetylcholine 1 receptor, NET norepinephrine transporter, NOS nitric oxide synthetase, SERT serotonin transporter, DAT dopamine transporter, σ1 sigma 1 receptor, M1 muscarinic acetylcholine 1 receptor, NOS nitric oxide synthetase, H1 histamine 1 receptor, σ1 sigma 1 receptor