Table 1.
Baseline characteristics in the total cohort stratified for BMI categories
| Characteristic | Underweight | Normal weight | Overweight | Obesity | p-value |
|---|---|---|---|---|---|
| n = 964 | n = 5219 | n = 4402 | n = 6027 | ||
| Anthropometric data | |||||
| BMI in kg/m2, median (IQR) | 17 (2) | 23 (3) | 27 (2) | 36 (9) | < 0.001* |
| Age in years, median (IQR) | 66 (24) | 68 (23) | 68 (21) | 64 (19) | < 0.001* |
| Age > 65 years, n (%) | 489 (51) | 2,925 (56) | 2479 (56) | 2814 (47) | < 0.001* |
| Elixhauser Comorbidity Index, median (IQR) | 3 (10) | 0 (10) | 0 (10) | 0 (9) | 0.003* |
| Risk parameter | |||||
| SOFA score points, median (IQR) | 5 (5) | 6 (5) | 5 (5) | 6 (6) | 0.004* |
| SOFA score > 10 points, n (%) | 106 (11) | 638 (12) | 573 (13) | 861 (14) | 0.002* |
| Heart rate > 110 bpm, n (%) | 283 (31) | 1347 (27) | 1145 (28) | 1368 (25) | < 0.001* |
| Body temperature > 38 °C, n (%) | 87 (10) | 500 (10) | 516 (12) | 769 (13) | < 0.001* |
| Biomarkers | |||||
| Creatinine mg/dL, median (IQR) | 1.0 (1.2) | 1.1 (1.3) | 1.3 (1.4) | 1.5 (1.6) | < 0.001* |
| Creatinine > 2.0 mg/dL, n (%) | 193 (22) | 1226 (25) | 1196 (29) | 2035 (36) | < 0.001* |
| Lactate mmol/L, median (IQR) | 1.9 (2.2) | 1.8 (1.9) | 1.8 (1.8) | 1.8 (1.8) | 0.12 |
| Lactate > 2.0 mmol/L, n (%) | 255 (47) | 1358 (44) | 1135 (43) | 1530 (42) | 0.14 |
| Length of stay in h | < 0.001* | ||||
| < 72 h, n (%) | 610 (63) | 3304 (63) | 2790 (63) | 3657 (61) | – |
| 72–168 h, n (%) | 257 (27) | 1255 (24) | 1065 (24) | 1524 (25) | – |
| > 168 h, n (%) | 97 (10) | 660 (13) | 547 (12) | 846 (14) | – |
| Fluid management in first 24 h | |||||
| Total amount of fluids in ml, median (IQR) | 2730 (3316) | 2725 (2885) | 2684 (2896) | 2673 (2881) | < 0.001* |
| Amount of fluid per kg bodyweight in ml, median (IQR) | 57 (67) | 43 (47) | 34 (37) | 25 (30) | < 0.001* |
| Amount of fluid per kg BW > 30 ml/kg/h, n (%) | 322 (71) | 1700 (65) | 1235 (57) | 1253 (42) | < 0.001* |
BMI body mass index, BW body weight, GI gastrointestinal, IQR interquartile range, SOFA sepsis-related organ failure assessment
* statistically significant