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. 2021 Dec 27;59(2):1183–1198. doi: 10.1007/s12035-021-02660-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — SEZ6L KO cerebellar proteome. Volcano plot of SEZ6L KO and WT cerebella with four biological replicates. The mean protein log2-transformed fold changes between SEZ6L KO and WT cerebella of each protein are plotted against the negative log10-transformed p-value. Proteins with a t-test p-value < 0.05 are shown as red circles. Proteins that remain significant after permutation-based FDR correction (FDR <0.05, s0= 0.1) are located above the hyperbolic curves. The straight dotted line crosses the y-axis at 1.3 and represents the p-value of 0.05.