Fig. 3.

SEZ6L KO mice show motor coordination deficits on the accelerating rotarod. On the accelerating rotarod (1–40 rpm, 3 trials/day over 5 days), female SEZ6L KO mice performed significantly worse than both WT and SEZ6L het mice (A). In contrast, male SEZ6L KO and WT mice performed similarly, although differences were seen between SEZ6L het and KO mice in later trials and between SEZ6L het and WT mice in trial 14 (B). Female cohort: WT n = 14, SEZ6L het n = 16, SEZ6L KO n = 15. Male cohort: WT n = 15, SEZ6L het n=18, SEZ6L KO n = 21. Data analysed with repeated measures 2-way ANOVA and shown as mean ± SEM. Significant WT vs. SEZ6L KO differences indicted with an asterisk (*), SEZ6L het vs. SEZ6L KO differences indicated with a hash (#) and WT vs. SEZ6L het differences indicated with $. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; ****p ≤ 0.0001 (or equivalent symbol)