Table 6.
Pairwise comparison of changes in MDRS slope over time according to mutation severity: estimate points/year (95% CI), p-value
| ref | GBA variant, DBS+ | GBA mild, DBS+ | GBA severe, DBS+ | GBA−DBS+ | ||||
|---|---|---|---|---|---|---|---|---|
| unweighted | weighted | unweighted | weighted | unweighted | weighted | unweighted | weighted | |
| GBA variant, DBS− | −1.15 (−1.72, −0.58), <0.0001 |
−1.16 (−1.71, −0.61), <0.0001 |
−2.46 (−3.07, −1.85), <0.0001 |
−2.26 (−2.93, −1.59), <0.0001 |
−2.33 (−2.92, −1.74), <0.0001 |
−2.52 (−3.13, −1.91), <0.0001 |
−0.44 (−0.89, 0.01), 0.06 |
−0.36 (−0.79, 0.07), 0.11 |
| GBA mild, DBS− | −0.77 (−1.75, 0.21), 0.12 |
−0.86 (−1.76, 0.04), 0.06 |
−2.08 (−3.1, −1.06), <0.0001 |
−1.97 (−2.95, −0.99), <0.0001 |
−1.95 (−2.95, −0.95), 0.0001 |
−2.23 (−3.17, −1.29), <0.0001 |
−0.06 (−1.04, 0.92), 0.91 |
−0.07 (−0.91, 0.77), 0.88 |
| GBA severe, DBS− | 0.05 (−0.97, 1.07), 0.92 |
0.53 (−0.47, 1.53), 0.30 |
−1.26 (−2.32, −0.2), 0.02 |
−0.58 (−1.64, 0.48), 0.28 |
−1.13 (−2.17, −0.09),0.03 |
−0.84 (−1.88, 0.2), 0.11 |
0.77 (−0.19, 1.73), 0.12 |
1.32 (0.38, 2.26), 0.01 |
| GBA−DBS− | −1.25 (−1.7, −0.8), <0.0001 |
−1.25 (−1.68, −0.82), <0.0001 |
−2.55 (−3.06, −2.04), <0.0001 |
−2.36 (−2.93, −1.79), <0.0001 |
−2.43 (−2.9, −1.96), <0.0001 |
−2.62 (−3.13, −2.11), <0.0001 |
−0.53 (−0.82, −0.24), 0.0004 |
−0.46 (−0.75, −0.17), 0.002 |