Table 2.
Comparison of patients’ characteristics and polysomnographic variables between REM-predominant OSA and REM-isolated OSA patients
| REM-predominant OSA (n = 395) | REM-isolated OSA (n = 79) | p Value | |
|---|---|---|---|
| Age (years) | 57 (46, 70) | 58 (44, 69) | 0.568 |
| Male (%) | 236 (59.7) | 39 (49.4) | 0.104 |
| BMI (kg/m2) | 25.6 (22.8, 29.3) | 23.4 (21.5, 25.8) | < .001* |
| ESS (points) | 8 (5, 11) | 6 (4, 11) | 0.115 |
| PSQI (points) | 7 (5, 11) | 9 (6, 13.5) | 0.030* |
| TST (min) | 455.0 (433.0, 487.0) | 457.0 (441.0, 493.5) | 0.536 |
| Percentage of REM sleep/TST (%) | 16.8 (12.1, 20.8) | 17.4 (12.0, 23.2) | 0.165 |
| Percentage of N1 sleep/TST (%) | 29.1 (19.4, 42.0) | 21.0 (14.6, 34.2) | < .001* |
| Percentage of N2 sleep/TST (%) | 51.9 (39.4, 61.3) | 57.2 (49.1, 65.7) | < .001* |
| Percentage of N3 sleep/TST (%) | 0 (0, 0.3) | 0 (0, 0.2) | 0.800 |
| AHI (events/h) | 17.6 (11.5, 25.5) | 6.8 (5.9, 7.9) | < .001* |
| AHI-REM (events/h) | 42.1 (29.1, 55.6) | 22.3 (17.7, 33.4) | < .001* |
| AHI-NREM (events/h) | 12.9 (8.1, 19.4) | 3.8 (2.9, 4.2) | < .001* |
| Nadir SpO2 (%) | 83.0 (78.0, 87.0) | 88.0 (84.0, 91.0) | < .001* |
| CT90 (%) | 0.8 (0.1, 2.3) | 0.1 (0, 0.5) | < .001* |
| PLMI (events/h) | 0 (0, 10.4) | 0 (0, 9.2) | 0.973 |
| ArI (events/h) | 24.5 (18.1, 32.1) | 18.8 (13.7, 25.1) | < .001* |
| Components of arousal threshold score | |||
| AHI < 30 events/h (%) | 340 (86.1) | 79 (100) | < .001* |
| Proportion of hypopneas > 58.3 (% of all events) | 306 (77.5) | 59 (74.7) | 0.660 |
| Nadir SpO2 > 82.5% (%) | 208 (52.7) | 66 (83.5) | < .001* |
| Proportion with arousal threshold score ≥ 2 (%) | 305 (77.2) | 74 (93.7) | < .001* |
| Male (%) | 179 (75.8) | 36 (92.3) | 0.021* |
| Female (%) | 126 (79.2) | 38 (95.0) | 0.019* |
| Medication | |||
| Hypnotics (%) | 126 (31.9) | 38 (48.1) | 0.007* |
| Antidepressants (%) | 31 (7.8) | 15 (19.0) | 0.006* |
| Antipsychotics (%) | 19 (4.8) | 8 (10.1) | 0.104 |
Continuous variables are expressed as medians and interquartile ranges (25th percentiles, 75th percentiles). Categorical variables are expressed as numbers (percentages). *p < 0.05
AHI apnea–hypopnea index, ArI arousal index, BMI body mass index, ESS Epworth Sleepiness Scale, N1 sleep stage 1, N2 sleep stage 2, N3 sleep stage 3, OSA obstructive sleep apnea, PSQI Pittsburgh Sleep Quality Index, REM rapid eye movement, SpO2 peripheral capillary oxygen saturation, TST total sleep time