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. 2021 Dec 6;477(3):649–661. doi: 10.1007/s11010-021-04290-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — miR-1246 regulates PIK3AP1. a KEGG analysis of the Top 20 signaling pathways affecting thyroid cancer development. b Boxplot result of TCGA-THCA analysis showing PIK3AP1 upregulation in thyroid cancer. c Predicting miR-1246-PIK3AP1 binding sites using the TargetScan Database. d Dual-luciferase analysis of miR-1246-PIK3AP1 binding. e Western blotting analysis of the protein levels of PIK3AP1, p-PI3K, PI3K, p-AKT, and AKT in TPC-1 and FTC-133 cells. *P < 0.05. KEGG Kyoto encyclopedia of genes and genomes, PIK3AP1 phosphoinositide 3-kinase adapter protein 1, NC negative control