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. 2021 Dec 28;59(2):1199–1213. doi: 10.1007/s12035-021-02653-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Atg7 KO reduces irradiation-induced OPC loss in the subcortical white matter a Representative images of OPCs in the subcortical white matter after irradiation that were immunostained for PDGFRα in WT-Sham and Atg7 KO-Sham and irradiated mouse pups. b Quantitative analysis of the PDGFRα-labeled cells in the subcortical white matter. c Bar graphs showing the mRNA expression of Olig2, Cldn11, CNP, and MBP in the cortical tissue, including the subcortical white matter, at 5 days after irradiation. n = 7/group for the immunostaining, and n = 5/group for qRT-PCR. *p < 0.05, **p < 0.01, ***p < 0.001.