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. 2021 Aug 21;269(3):1335–1352. doi: 10.1007/s00415-021-10739-8

Table 1.

Descriptive features of the 117 eligible studies included in the evaluation of screening, diagnosis, QoL and prognosis

Topic domain All studies Number of patients = number of studies Cross-sectional/prospective studies Case–control/retrospective study Class of evidence
N N N N N
Screening and diagnosis of dysphagia in PD 82

 < 10 pts = 1

10–19 pts = 16 studies

20–50 pts = 28 studies

 > 50 pts = 37 studies

58 24

4 Class I

4 Class II

18 Class III

56 Class IV

QoL and prognosis of dysphagic patients with PD 35

 < 50 pts = 13

50–199 pts = 13

200–500 pts = 5

 > 500 pts = 4

20 15

4 Class I

8 Class II

8 Class III

15 Class IV

Studies were classified according to various descriptors, including topic domain, sample size, design, presence of diagnostic criteria of the syndrome and level of evidence according to the Classification of Evidence Schemes of the Clinical Practice Guideline Process Manual of the American Academy of Neurology 17. Each study was graded according to its risk of bias from Class I to Class IV (with I corresponding to the highest quality and IV to the lowest quality)