Table 1.
Baseline characteristics
| BRCA1/2-PV carriers (n = 577) | ||
|---|---|---|
| Mean/N | SD/% | |
| Age, years | 37.2 | 3.5 |
| Pathogenic variant | ||
| BRCA1 | 297 | 51.5% |
| BRCA2 | 280 | 48.5% |
| Years since BRCA1/2-PV diagnosis | 5.0 | 4.6 |
| Chosen risk-reducing surgery | ||
| RRSO | 164 | 28.4% |
| RRS with delayed RRO | 413 | 71.6% |
| Educational level | ||
| Low | 64 | 11.1% |
| Intermediate | 205 | 35.5% |
| High | 296 | 51.3% |
| Unknown | 12 | 2.1% |
| Employment status | ||
| Employed | 466 | 80.8% |
| Unemployed | 92 | 15.9% |
| Unknown | 17 | 2.9% |
| Relationship status | ||
| Married/relationship | 511 | 88.6% |
| Single/divorced/widowed | 54 | 9.4% |
| Unknown | 12 | 2.1% |
| Offspring | ||
| Yes | 497 | 86.1% |
| No | 65 | 11.3% |
| Unknown | 15 | 2.6% |
| History of cancer | ||
| Breast | 81 | 14.3% |
| Othera | 5 | 0.9% |
| Risk-reducing mastectomy | ||
| Yes | 223 | 38.6% |
| No | 342 | 59.3% |
| Unknown | 12 | 2.1% |
| (History of) emotional instabilityb | ||
| Yes | 97 | 16.8% |
| No | 468 | 81.1% |
| Unknown | 12 | 2.1% |
| Medication use | ||
| Antidepressants | 32 | 5.5% |
| Antipsychotics | 1 | 0.2% |
| Benzodiazepines | 10 | 1.7% |
| First degree family history | ||
| Breast cancer | 266 | 6.1% |
| Ovarian cancer | 77 | 13.3% |
aOther cancers included non-melanoma skin cancer (3 women), cervical cancer
(1 woman) and an appendicular neoplasm (1 woman)
bEmotional instability is defined as self-reported current or previous severe anxiety, burn-out and/or depression