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. 2022 Jan 3;59(2):1238–1248. doi: 10.1007/s12035-021-02656-8

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Fig. 2 — Altered rat hippocampal mRNA expression of cannabinoid receptors (CB/Cnr) as a result of METH SA followed by contingent footshocks. Quantitative RT-PCR (qRT-PCR) data on the mRNA expression of the cannabinoid receptors, CB1/Cnr1 (a) and CB2/Cnr2 (b). One-way ANOVA analysis of the data revealed significant changes in CB1/Cnr1 expression (p = 0.0001) and CB2/Cnr2 expression (p = 0.0017). Post hoc analyses showed significant increases in both receptor mRNA levels in the SS group compared to the CT, YSS, and SR groups. Key to statistics: **P < 0.01, ***P < 0.001, compared with controls; !!!P < 0.001, comparison to yoked shock sensitive (YSS); #P < 0.05, ###P < 0.001, comparison to compulsive METH (SR) group