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. 2022 Jan 3;59(2):1238–1248. doi: 10.1007/s12035-021-02656-8

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Fig. 3 — Effect of METH SA and contingent footshock on rat hippocampal mRNA expression of key cannabinoid enzymes within the ECS cascade. Data from qRT-PCR showed significant increase in the mRNA expression of the synthesizing enzyme Dagla (b) in SS rats in comparison to CT, YSS, and SR rats (p < 0.01). Among the metabolizing enzymes, significant changes in the expression of Faah (p = 0.0004) and Mgll (p = 0.0015) were also observed where significant increases in mRNA levels were noted in the SS rats compared to the YSS, YSR, and SR rats. Significant decreases in Ptgs2 (p = 0.0003) mRNA levels were noted in the SS, YSR, and YSS groups in comparison to the CT group. Key to statistics: *P < 0.05, **P < 0.01, compared with controls; !!!P < 0.001, comparison to yoked shock sensitive (YSS); #P < 0.05, ##P < 0.01, comparison to compulsive METH (SR) group