Table 1.
Demographic and clinical characteristics of HC, PD-non pRBD, and PD-pRBD females and males
| HC | PD-non pRBD | PD-pRBD | Sex main effect test stat (P value) | |
|---|---|---|---|---|
| Age, years | ||||
| F | 60.6 (5.9) | 60.9 (7.4) | 63.5 (7.5) | 6.215 (0.013)* |
| M | 64.1 (7.1) | 63.2 (7.4) | 64.7 (7.0) | |
| Education, years | ||||
| F | 16.2 (2.9) | 15.4 (2.9) | 15.2 (3.1) | 3.141 (0.077) |
| M | 17.0 (2.5) | 15.8 (3.0) | 16.1 (2.9) | |
| Age of onset, years | ||||
| F | NA | 60.0 (7.4) | 62.6 (7.6) | 2.348 (0.127) |
| M | NA | 62.3 (7.2) | 63.6 (6.9) | |
| PD duration, months | ||||
| F | NA | 10.8 (8.5) | 9.9 (6.8) | 0.278 (0.599) |
| M | NA | 10.3 (6.2) | 11.6 (7.2) | |
| MDS-UPDRS | ||||
| F | NA | 28.4 (10.0) | 32.0 (11.9) | 3.774 (0.053) |
| M | NA | 30.1 (11.3) | 37.4 (14.1) | |
| MDS-UPDRS Part III | ||||
| F | NA | 19.0 (7.6) | 17.9 (7.6) | 7.371 (0.007)** |
| M | NA | 20.4 (8.3) | 23.3 (9.4) | |
| H&Y stage, n, 1/2/3 | ||||
| F | NA | 1.7 (2.1) | 2.6 (2.5) | 0.002 (0.967) |
| M | NA | 35/37/1 | 21/33/0 | |
| GDS-15 | ||||
| F | 1.9 (3.2) | 1.7 (2.1) | 2.6 (2.5) | 0.002 (0.967) |
| M | 1.2 (2.8) | 2.3 (2.2) | 2.7 (2.4) | |
| ESS | ||||
| F | 4.6 (2.9) | 4.9 (3.4) | 6.8 (3.6) | 0.822 (0.365) |
| M | 5.3 (3.5) | 5.7 (2.9) | 6.4 (3.7) | |
| RBDSQ | ||||
| F | 1.5 (1.2) | 2.7 (1.1) | 6.0 (1.4) | 7.405 (0.007)** |
| M | 1.9 (1.4) | 2.6 (1.1) | 7.2 (1.9) | |
| UPSIT | ||||
| F | 34.9 (3.4) | 23.8 (8.6) | 21.4 (8.7) | 3.401 (0.066) |
| M | 33.6 (4.1) | 21.0 (7.4) | 18.7 (8.0) | |
Data are presented by groups as mean (SD), except for H&Y. Two-way analyses of variance (ANOVA) followed by Bonferroni post hoc tests were used for all demographic variables. Two-way analyses of covariance (ANCOVA) with age as covariable, followed by Bonferroni post hoc tests were used for all clinical variables. Except for MDS-UPDRS, that was analyzed by two-way analysis of variance (ANOVA); and H&Y, by Pearson’s Chi-squared
ESS Epworth Sleepiness Scale; F female; GDS-15 the 15-item Geriatric Depression Scale; HC healthy controls; H&Y Hoehn and Yahr scale; M male; MDS-UPDRS Movement Disorder Society Unified Parkinson’s Disease Rating Scale; PD-non pRBD PD without probable RBD; PD-pRBD PD with probable RBD; RBDSQ REM Sleep Behavior Disorder Screening Questionnaire; UPSIT University of Pennsylvania Smell Identification Test
*Sex differences in HC group (P < 0.05)
**Sex differences in PD-pRBD group (P < 0.05)