Table 1.
Comparison of characteristics and biomarkers by group
| CAA (n = 10) | AD (n = 20) | CS (n = 10) | Group comparison, p value | Post hoc comparisons; p values | |||
|---|---|---|---|---|---|---|---|
| CAA/AD | CAA/CS | AD/CS | |||||
| Age, years, mean (SD) | 68.6 (3.0) | 62.5 (4.1) | 62.2 (5.4) | 0.001 | – | – | – |
| Sex, female, n (%) | 2 (20%) | 11 (55%) | 5 (50%) | 0.18 | – | – | – |
| MMSE, median (IQR) | 29 (28 to 30) | 24 (19.5 to 26) | 29 (29 to 30) | < 0.001 | – | – | – |
| CSF biomarkers | |||||||
| Ferritin, ng/ml, median (IQR) | 10.10 (8.37 to 14.00) | 7.77 (6.39 to 9.18) | 8.01 (6.94 to 8.95) | 0.0136 | 0.0060 | 0.0483 | 1.0000 |
| Iron, concentration (μg/L), median (IQR) | 23.42 (18.82 to 25.30) | 15.48 (12.28 to 18.26) | 17.71 (15.19 to 20.76) | 0.0015 | 0.0006 | 0.0912 | 0.2268 |
Group comparison p values were obtained using one-way ANOVA (age), Chi-squared tests (sex), or Kruskal–Wallis tests (remainder). Post hoc comparisons were made using Dunn’s test; the presented p values are Bonferroni-corrected
AD Alzheimer’s disease, CAA cerebral amyloid angiopathy, CS control subjects, IQR interquartile range, MMSE mini-mental state examination, SD standard deviation