Table 4.
Predictors of ischemic stroke during follow-up
| No IS on FU N = 171 |
IS on FU N = 19 |
Univariable analysis | Multivariable analysis | |||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |||
| Age, mean (SD) | 74.5 (9) | 74.6 (6.5) | 1.01 | 0.95–1.07 | 0.8 | 1 | 0.94–1.07 | 0.9 |
| Female sex, N (%) | 79 (46.2) | 7 (36.8) | 0.72 | 0.28–1.85 | 0.5 | |||
| Smoker | 15/150a (10) | 2 (10.5) | 1.25 | 0.28–5.56 | 0.77 | |||
| Drinker | 19/131 (14.5) | 3/18 (16.7) | 1.83 | 0.5–6.7 | 0.36 | |||
| PMH | ||||||||
| HTN, N (%) | 103 (60.2) | 14 (73.7) | 1.71 | 0.61–4.81 | 0.31 | |||
| Hypercholesterolemia, N (%) | 78 (45.6) | 7 (36.8) | 0.71 | 0.27–1.88 | 0.49 | |||
| DM, N (%) | 22 (12.9) | 4 (21.1) | 1.71 | 0.55–5.34 | 0.36 | |||
| AF, N (%) | 15/2167 (9) | 3 (15.8) | 2 | 0.55–7.33 | 0.3 | |||
| OAC use, N (%) | 11/166 (6.6) | 4 (21.1) | 3.63 | 1.13–11.68 | 0.03 | 3.44 | 1.07–11.06 | 0.04 |
| Antiplatelet use, N (%) | 56/166 (33.7) | 7 (36.8) | 1.06 | 0.4–2.77 | 0.91 | |||
| Statin use, N (%) | 60/166 (36.1) | 6 (31.6) | 0.86 | 0.32–2.32 | 0.77 | |||
| Anti HTN use, N (%) | 93/166 (56) | 11 (5791) | 1.02 | 0.4–2.6 | 0.97 | |||
| Previous ICH, N (%) | 23 (13.5) | 1 (5.3) | 0.36 | 0.05–2.71 | 0.32 | |||
| Previous IS, N (%) | 18/170 (10.6) | 3 (15.8) | 1.75 | 0.49–6.21 | 0.39 | |||
| Restart antiplatelet, N (%) | 48/152 (31.6) | 6 (31.6) | 1.14 | 0.42–3.13 | 0.79 | |||
| Restart OAC, N (%) | 12/150 (8) | 1 (5.3) | 0.53 | 0.07–4.07 | 0.54 | |||
| Probable CAA, N (%) | 138 (80.7) | 15 (78.9) | 0.55 | 0.16–1.81 | 0.32 | 0.56 | 0.17–1.82 | 0.33 |
| cSS, N (%) | 155/169 (91.7) | 15 (79) | 0.39 | 0.12–1.24 | 0.11 | |||
| CMB, N (%) | 110/168 (65.5) | 15 (79) | 1.15 | 0.36–3.67 | 0.82 | |||
| WMH, N (%) | 107/157 (68.2) | 13 (68.4) | 0.73 | 0.26–2.06 | 0.56 | |||
AF atrial fibrillation, CAA cerebral amyloid angiopathy, CI confidence interval, CMB cerebral microbleeds, cSS cortical superficial siderosis, DM diabetes mellitus, DWI diffused white matter, FU follow-up, HR Hazard Ratio, HTN hypertension, OAC oral anticoagulation, PMH past medical history, preICH previous intracerebral hemorrhage, preIS previous ischemic stroke, SD standard deviation, WMH white matter hyperdensity
aIn case of missing values in the predictors the number is displayed as a fraction and percentage is based on complete cases