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. 2022 Feb 18;13(2):160. doi: 10.1038/s41419-021-04471-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Binding sites of miR-302a on the 3′UTR of lncRNA HOXA-AS2 predicted by the DIANA TOOLS, RAID v2.0 and TargetScan databases. B miR-302a expression in tumor tissues of patients with glioma (N = 40) and normal brain tissues (N = 10) determined by RT-qPCR. C Correlation between miR-302a expression and lncRNA HOXA-AS2 expression in glioma tissues (N = 40) analyzed by Pearson’s correlation coefficient. D miR-302a expression in 293 T cells transfected with miR-302a mimic determined by RT-qPCR. E, miR-302 binding to lncRNA HOXA-AS2 confirmed by dual-luciferase reporter gene assay in 293 T cells. F Binding sites of miR-302a on the 3′UTR of KDM2A mRNA predicted by the DIANA TOOLS, RAID v2.0 and TargetScan databases. G KDM2A expression in glioma tissues (N = 40) and normal brain tissues (N = 10) determined by RT-qPCR. H Correlation analysis between KDM2A expression and miR-302a expression in glioma tissues (N = 40) analyzed by Pearson’s correlation coefficient. I miR-302a binding to KDM2A validated by dual-luciferase reporter gene assay in 293 T cells. J Enrichment of KDM2A and lncRNA HOXA-AS2 analyzed by RIP in 293 T cells. K Expression of lncRNA HOXA-AS2, miR-302a and KDM2A in 293 T cells transfected with sh-lncRNA HOXA-AS2 or combined with miR-302a inhibitor determined by RT-qPCR. *p < 0.05. Data were shown as the mean ± standard deviation. Statistical comparisons were performed using unpaired t-test when only two groups were compared or by one-way ANOVA with Tukey’s post hoc test when more than two groups were compared. Cell experiments were repeated three times.