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. 2022 Feb 18;13(2):160. doi: 10.1038/s41419-021-04471-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — BALB/c mice were injected with LN229 cell suspension stably infected with lentivirus harboring sh-NC + oe-NC, sh-lncRNA HOXA-AS2 + oe-NC or sh-lncRNA HOXA-AS2 + oe-JAG1. A LncRNA HOXA-AS2, KDM2A, JAG1, and miR-302a expression in tumor tissues of BALB/c mice determined by RT-qPCR. B KDM2A and JAG1 expression in tumor tissues of BALB/c mice determined by IHC. C Measurement of tumor volume and weight of BALB/c mice. D Ratio of CD4⁺CD25⁺Foxp3⁺ cells in tumor tissues of BALB/c mice analyzed by flow cytometry. E IL-10, TGF-β, IFN-γ, and TNF-α levels in the BALB/c mouse spleen tissues determined by ELISA. F The tumor volume and weight of BALB/c mice and nude mice. WT indicates normal BALB/c mice and nude indicates immunocompromised nude mice. *p < 0.05. Data were shown as the mean ± standard deviation. Statistical comparisons were performed using one-way ANOVA with Tukey’s post hoc test when more than two groups were compared. Variables were analyzed at different time points using Bonferroni-corrected repeated measures ANOVA. n = 8.