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. 2022 Feb 18;12:2788. doi: 10.1038/s41598-022-06545-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A,B) The serum levels of glutamic-oxaloacetic transaminase (GOT—A) and glutamic-pyruvic transaminase (GPT—B) in Bio-C Temp, Calen and Control groups at 7 and 60 days. In rats with intracanal medication, the GOT and GPT levels were similar to CG rats. From 7 to 60 days, significant differences are not seen in the serum GOT and GPT levels. Values expressed as mean ± SD. Tukey’s test (p ≤ 0.05). In each period, superscript letters indicate the analysis among groups; same letters = no significant difference. The superscript numbers indicate the analysis of each group over time; same numbers = no significant difference.