Table 2.

Risk factors for OMG generalization in univariable Cox proportional hazards regression model

Risk factors	Before multiply-imputed		After multiply-imputed
	HR (95% CI)	p value	HR (95% CI)	p value
Sex
Male	1		1
Female	1.14 (0.82–1.58)	0.44	1.14 (0.82–1.58)	0.44
Age at onset, years
< 18	1		1
18–49	7.23 (2.25–23.18)	< 0.001	7.23 (2.25–23.18)	< 0.001
≥ 50	10.89 (3.44–34.51)	< 0.001	10.89 (3.44–34.51)	< 0.001
Symptoms at onset
Ptosis	1		1
Diplopia/diplopia and ptosis	1.48 (1.07–2.06)	0.02	1.48 (1.07–2.06)	0.02
Comorbid autoimmune diseasesa
No	1		1
Yes	0.89 (0.37–2.18)	0.81	0.89 (0.37–2.18)	0.81
RNS findings
Normal	1		1
Abnormal	3.32 (2.19–5.03)	< 0.001	3.51 (2.37–5.19)	< 0.001
AChR-Ab
Seronegative	1		1
Seropositive	5.09 (2.59–10.02)	< 0.001	4.61 (2.49–8.52)	< 0.001
Thymic status
Non-thymoma	1		1
Thymoma	2.13 (1.46–3.11)	< 0.001	2.14 (1.46–3.12)	< 0.001

CI Confidence interval, HR hazard ratio

^aComorbid autoimmune diseases included systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, Hashimoto's thyroiditis, and optic neuromyelitis spectrum disease