Table 1.
Characteristics of vasculitis in the study cohort
| TAK | GCA | GPA | MPA | EGPA | PAN | IgAV | |
|---|---|---|---|---|---|---|---|
| Total number of patients | 170 | 657 | 555 | 223 | 146 | 48 | 153 |
| Gender, n (%) | |||||||
| Male | 28 (16.5) | 225 (34.2) | 287 (51.7) | 98 (44.0) | 78 (53.4) | 27 (56.2) | 85 (55.6) |
| Female | 142 (83.5) | 432 (65.8) | 268 (48.3) | 125 (56.0) | 68 (46.6) | 21 (43.8) | 68 (44.4) |
| Age at diagnosis, mean (s.d.) | 34.5 (12.1) | 72.0 (9.1) | 53.0 (16.5) | 64.2 (13.2) | 53.3 (15.2) | 46.2 (19.1) | 51.2 (21.0) |
| Ethnicity, no. of patients | |||||||
| African | 3 | 2 | 3 | 0 | 1 | 1 | 0 |
| African American | 0 | 3 | 1 | 2 | 2 | 0 | 0 |
| Asian | 13 | 7 | 20 | 49 | 10 | 2 | 14 |
| Caucasian | 10 | 56 | 76 | 29 | 32 | 9 | 13 |
| European | 38 | 554 | 314 | 104 | 72 | 21 | 107 |
| Indian | 40 | 2 | 38 | 5 | 9 | 3 | 3 |
| Latin American | 4 | 2 | 14 | 2 | 4 | 0 | 0 |
| Middle Eastern | 59 | 16 | 53 | 13 | 6 | 10 | 10 |
| Other | 8 | 20 | 48 | 22 | 13 | 2 | 6 |
| History of smoking, n (%) | 3 (1.8) | 17 (2.6) | 39 (7.0) | 28 (12.6) | 28 (19.2) | 1 (2.1) | 2 (1.3) |
| Comorbidities, n (%) | |||||||
| Asthma | 5 (2.9) | 39 (5.9) | 26 (4.7) | 4 (1.8) | 97 (66.4) | 4 (8.3) | 8 (5.2) |
| COPD | 1 (0.6) | 29 (4.4) | 11 (2.0) | 17 (7.6) | 5 (3.4) | 0 | 5 (3.3) |
| Serology, positive/available (%) | |||||||
| cANCA | 2/58 (3.4) | 7/311 (2.3) | 383/480 (79.8) | 17/178 (9.6) | 10/127 (7.9) | 1/39 (2.6) | 4/121 (3.3) |
| pANCA | 1/60 (1.7) | 20/301 (6.6) | 55/456 (12.1) | 163/183 (89.1) | 58/129 (45.0) | 3/41 (7.3) | 7/123 (5.7) |
| PR3-ANCA | 1/51 (1.9) | 3/281 (1.1) | 434/523 (83.0) | 11/212 (5.2) | 4/126 (3.2) | 1/32 (3.1) | 3/129 (2.3) |
| MPO-ANCA | 0/52 | 9/284 (3.2) | 47/503 (9.3) | 201/216 (93.1) | 65/129 (50.4) | 0/32 | 3/132 (2.2) |
| anti-GBM | 0/6 | 1/27 (3.7) | 3/182 (1.6) | 5/133 (3.8) | 0/21 | 0/7 | 0/15 |
| RF | 6/55 (10.9) | 22/264 (8.3) | 135/313 (43.1) | 56/144 (38.9) | 40/93 (43.0) | 6/28 (21.4) | 4/107 (3.7) |
| ACPA | 0/22 | 6/98 (6.1) | 9/141 (6.4) | 2/60 (3.3) | 1/31 (3.2) | 1/7 (14.3) | 0/23 |
| ANA | 20/95 (21.1) | 58/340 (17.1) | 54/417 (12.9) | 67/196 (34.2) | 21/122 (17.2) | 10/40 (25.0) | 14/139 (10.1) |
TAK: Takayasu’s arteritis; GPA: granulomatosis with polyangiitis; MPA: microscopic polyangiitis; EGPA: eosinophilic GPA; PAN: polyarteritis nodosa; IgAV, IgA vasculitis; COPD: chronic obstructive pulmonary disease; c: cytoplasmic; p: perinuclear; MPO: myeloperoxidase; anti-GBM: anti-glomerular basement membrane antibodies.