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. 2022 Feb 19;41:69. doi: 10.1186/s13046-022-02285-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — YTHDF3/DICER1-AS1/DICER1/miR-5586-5p axis is pivotal for glycolysis and tumorigenesis of PC. A The representative IHC images of DICER1, YTHDF3, SLC2A1, LDHA, HK2, and PGK1 in PC tissues (n = 86) with low or high levels of DICER1-AS1. Scale bar, 100 μm. B Statistical analyses (Chi-square test) showing the different levels of DICER1, YTHDF3, SLC2A1, LDHA, HK2, and PGK1 in PC tissues with high or low DICER1-AS1 levels. C Kaplan–Meier analysis (log-rank test) showing the OS curves based on the different groups of PC patients (TCGA database) with different levels of DICER1-AS1, DICER1, miR-5586-5p, and YTHDF3. D The images of xenografts formed by subcutaneous injection of BxPC-3 cells transfected with LV-NC or LV-DICER1-AS1. E The volume of the subcutaneous tumor was measured every 5 days in indicated groups (left panel). The weight of subcutaneous tumor was measured in the indicated groups after mice were sacrificed (right panel). F The representative HE staining images (left panel) and quantification (right panel) of lung tissues were isolated from indicated groups. The nude mice were treated with tail vein injection of BxPC-3 cells transfected with LV-NC or LV-DICER1-AS1. G Schematic representation for the mechanism of YTHDF3/DICER1-AS1/DICER1/miR-5586-5p axis as a switch that regulates glycolysis in pancreatic cancer by stabilizing the glycolytic genes under glucose deprivation. All data were presented as means ± SD of at least three independent experiments. Values are significant at ^aP < 0.05, ^bP < 0.01 and ^cP < 0.001 as indicated