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. 2022 Feb 18;20:86. doi: 10.1186/s12951-022-01283-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — miRNA-29a-3p enhanced PD-L1 expression by targeting PTEN expression. A Enhanced expression of PD-L1 at mRNA level in pEXO-educated monocyte (n = 8). B Flow cytometry analysis of the expression of PD-L1 on pEXO-educated monocytes. N = 3, each dot represents one sample. C Increased frequencies of CD14⁺PD-L1⁺ monocytes from pregnant women and non-pregnant control. (Right). N = 11, each dot represents one sample. Non-p: non-pregnant; P: pregnant. D Representative histogram of PD-L1 expression in monocyte after miRNAs transfection. E Quantitative analysis of PD-L1 level in monocyte after miRNAs transfection. F Overlapped target genes between miRNA-10-5p, miRNA-22-3p and miRNA-29-3p by TargetScan 7.2 predication. G Western Blot analysis of PTEN expression after miRNAs mimics transfection. H Quantitative analysis of PTEN expression 24 h after miRNA-29a-3p mimics transfection. I The level of PTEN in monocytes of pregnant women and non-pregnant women (P & Non-P). J Quantitative analysis of PTEN expression of the circulating monocytes of pregnant women and non-pregnant women. (N = 3) *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 compared to the control group