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. 2022 Feb 18;22:86. doi: 10.1186/s12935-022-02489-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — MeCP2 knockdown improved the 5-FU sensitivity of 5-FU-resistant GC cells. Cell viability in GC cells and 5-FU-resistant GC cells treated respectively with 0, 0.1, 0.5, 1, 5, 10, 20, 40, 80 and 160 μM 5-FU for 48 h (A, B). Interferential efficiency of MeCP2 in 5-FU resistant GC cells transfected with siRNA-1 or siRNA-2 targeting to MeCP2, or NC-siRNA, or siRNA-1 or siRNA-2 plus MeCP2-overexpressing plasmid (*p < 0.05, as compared with NC-siRNA; ^#p < 0.05, as compared with siRNA-1 or siRNA-2; Student's t-test) (C, D). Cell viability (E, F), colony formation (G, H), cell cycle (I, J) and cell apoptosis (K, L) were detected in 5-FU resistant GC cells transfected with siRNA-1 or siRNA-2 targeting to MeCP2, or with NC-siRNA, or with siRNA-1 or siRNA-2 + ov-MeCP2, and then treated with 5-FU (*p < 0.001, as compared with NC-siRNA; ^#p < 0.001, as compared with NC-siRNA + 5-FU; Student's t-test)