Table 10.
T cell epitope content comparison (EpiCC) analysis
Treatment Group (T) and description | EpiCC scores | Percent coverage | % Improvement of homologous vs heterologous coverage a | ||||
---|---|---|---|---|---|---|---|
Vaccine | Challenge | PCV2a ORF2 b | PCV2b ORF2 c | PCV2a ORF2 b | PCV2b ORF2 c | ||
T02 homologous treatment | cPCV2a | PCV2a | 10.42 d | 7.51 | 100.00 | 72.05 | 36.46 |
T04 heterologous treatment | cPCV2a | PCV2b | 7.51 | 10.25 d | 73.28 | 100.00 |
a The percent improvement of homologous (cPCV2a vaccine, PCV2a challenge) versus heterologous (cPCV2a vaccine, PCV2b challenge) coverage (|(heterologous-homologous)|/heterologous * 100%) representing the situation in Study A.
b Situation tested in studies A and B.
c Situation tested in study C.
d Represents baseline where the challenge strain is identical to the vaccine strain.