Fig. 6.

H2B variant expression during human gametogenesis and embryogenesis. RNA expression of H2B variants (reads per kilobase per million mapped reads, RPKM) in publicly available bulk RNA-seq data across different stages of (A) human spermatogenesis, (B) human oogenesis, and (C) human embryogenesis. Legend shows colors corresponding to each histone variant (note that H2B.L is pseudogenized in humans). The bar heights show median RPKMs of biological replicates and error bars show median absolute deviations. See supplementary figure S14, Supplementary Material online, for additional analyses of H2B variants’ expression in somatic and reproductive tissues of other mammals.