Fig. 1.

Different doses of isoflurane conditioning attenuates SAH-induced vasospasm in wild type mice: Mice underwent sham or SAH surgery and exposed to isoflurane 0.5%, 1% or 2% for 1-hour, one-hour post SAH. On post-surgery day 3, mice were perfused with ROX-SE staining and vessel diameter in the proximal MCA ipsilateral to suture perforation was measured. Data indicate mean ± SEM. *p < 0.05 sham vs. SAH, SAH vs. SAH + Isoflurane conditioning, by ANOVA and Newman-Keuls multiple comparison test. SAH- subarachnoid hemorrhage, ROX-SE, 5-(and-6)-Carboxy-X-rhodamine, succinimidyl ester, MCA- middle cerebral artery, ANOVA- analysis of variance.