Table 2.

Hazard ratios for time-to-event uutcomes for new users of fine-particle fixed dose fluticasone and extra fine fixed dose beclometasone in propensity score matched samples

Outcome	Number of Patients	Number of Patients with ≥ 1 Event (%)	HR	95% CI	p-value
Primary outcomes
Sensitive pneumonia definition
Unmatched	20,048	584 (2.9%)	1.41	1.20–1.66	P < 0.001
Propensity score matched	13,316	399 (3.0%)	1.38	1.14–1.68	P = 0.001
Specific pneumonia definition
Unmatched	20,048	471 (2.3%)	1.30	1.09–1.56	P = 0.004
Propensity score matched	13,316	322 (2.4%)	1.31	1.05–1.62	P = 0.015
Secondary outcomes
Respiratory outcome
URTI & LRTI
Unmatched	20,048	5327 (26.6%)	1.09	1.03–1.15	P = 0.002
Propensity score matched	13,316	3535 (26.8%)	1.08	1.01–1.16	P = 0.019
LRTI only
Unmatched	20,048	4817 (24.1%)	1.09	1.03–1.15	P = 0.004
Propensity score matched	13,316	3200 (24.3%)	1.08	1.01–1.15	P = 0.036
Exploratory outcomes
Acute OCS use
Unmatched	20,048	7099 (35.5%)	1.06	1.01–1.11	P = 0.023
Propensity score matched	13,316	4795 (36.1%)	1.04	0.98–1.10	P = 0.178
Antibiotic prescription
Unmatched	20,048	6502 (32.5%)	1.08	1.03–1.13	P = 0.003
Propensity score matched	13,316	4351 (32.8%)	1.03	0.97–1.10	P = 0.294
Exacerbation
Unmatched	20,048	8998 (45.1%)	1.09	1.05–1.14	P<0.001
Propensity score matched	13,316	6042 (45.5%)	1.06	1.01–1.11	P=0.028
Primary care recorded hospitalization
Unmatched	20,048	6567 (32.5%)	0.98	0.94–1.03	P = 0.445
Propensity score matched	13,316	4459 (33.9%)	1.02	0.96–1.08	P = 0.493
Pneumonia related hospitalization
Unmatched	20,048	302 (2.5%)	1.41	1.12–1.77	P = 0.003
Propensity score matched	13,316	223 (1.7%)	1.44	1.11–1.88	P = 0.007

Abbreviations: CI, confidence interval; HR, hazard ratio; LTRI, Lower Tract Respiratory Infection; OCS, oral corticosteroids; UTRI, Upper Tract Respiratory Infection.