Table 3.

Hazard ratios for comparing time-to-event uutcomes for new users of fine-particle fixed dose fluticasone-propionate (fp-FDC-FP) or -furoate (fp-FDC-FF) and extra fine fixed dose beclometasone (ef-FDC-BDP) in propensity score matched samples

Outcome	Fine Fixed Dose Fluticasone Propionate				Fine Fixed Dose Fluticasone Furoate
	Number of Patients	HR	95% CI	p-value	Number of Patients	HR	95% CI	p-value
Primary outcomes
Sensitive pneumonia definition
Unmatched	9740 ef-FDC-BDP, 6096 fp-FDC-FP	1.43	1.19–1.72	P < 0.001	9740 ef-FDC-BDP, 4212 fp-FDC-FF	1.37	1.11–1.70	P = 0.004
Propensity score matched	3808 ef-FDC-BDP, 3808 fp-FDC-FP	1.64	1.26–2.12	P < 0.001	3449 ef-FDC-BDP, 3449 fp-FDC-FF	1.34	1.01–1.78	P = 0.040
Specific pneumonia definition
Unmatched	9740 ef-FDC-BDP, 6096 fp-FDC-FP	1.22	0.99–1.51	P = 0.059	9740 ef-FDC-BDP, 4212 fp-FDC-FF	1.43	1.14–1.80	P = 0.002
Propensity score matched	3808 ef-FDC-B, 3808 fp-FDC-FP	1.45	1.09–1.94	P = 0.012	3449 ef-FDC-BDP, 3449 fp-FDC-FF	1.30	0.96–1.77	P = 0.085
Secondary outcomes
Respiratory outcome
URTI & LRTI
Unmatched	9740 ef-FDC-BDP, 6096 fp-FDC-FP	1.18	1.12–1.26	P < 0.001	9740 ef-FDC-BDP, 4212 fp-FDC-FF	0.95	0.88–1.02	P = 0.135
Propensity score matched	3808 ef-FDC-BDP, 3808 fp-FDC-FP	1.12	1.04–1.22	P = 0.006	3449 ef-FDC-BDP, 3449 fp-FDC-FF	1.08	0.99–1.19	P = 0.092
LRTI only
Unmatched	9740 ef-FDC-BDP, 6096 fp-FDC-FP	1.18	1.11–1.26	P < 0.001	9740 ef-FDC-BDP, 4212 fp-FDC-FF	0.95	0.88–1.03	P = 0.195
Propensity score matched	3808 ef-FDC-BDP, 3808 fp-FDC-FP	1.14	1.05–1.25	P = 0.002	3449 ef-FDC-BDP, 3449 fp-FDC-FF	1.06	0.96–1.17	P = 0.280

Abbreviations: CI, confidence interval; ef-FDC-B, extrafine fixed dose combination beclometasone; fp-FDC-FP, fine-particle fixed dose fluticasone furoate; fp-FDC-FP, fine-particle fixed dose fluticasone propionate; HR, hazard ratio; LRTI, Lower Tract Respiratory Infection; URTI, Upper Tract Respiratory Infection.