Table 1.
Multivariable MR Associations of Cardiac Troponin I with Stroke and Its Subtypes Adjusted for Atrial Fibrillation and BMI
| Outcome | Model | OR (95% CI) | P-value |
|---|---|---|---|
| AS | IVW adjusted for atrial fibrillation | 1.00 (0.85, 1.17) | 0.996 |
| IVW adjusted for smoking | 1.02 (0.88, 1.18) | 0.764 | |
| IVW adjusted for BMI | 1.03 (0.88, 1.20) | 0.747 | |
| Fully adjusted model | 0.99 (0.83, 1.19) | 0.918 | |
| AIS | IVW adjusted for atrial fibrillation | 1.08 (0.86, 1.36) | 0.503 |
| IVW adjusted for smoking | 1.08 (0.88, 1.33) | 0.47 | |
| IVW adjusted for BMI | 1.09 (0.87, 1.36) | 0.466 | |
| Fully adjusted model | 1.09 (0.80, 1.48) | 0.583 | |
| LAS | IVW adjusted for atrial fibrillation | 1.08 (0.86, 1.36) | 0.503 |
| IVW adjusted for smoking | 1.10 (0.74, 1.63) | 0.64 | |
| IVW adjusted for BMI | 1.04 (0.67, 1.59) | 0.87 | |
| Fully adjusted model | 1.23 (0.75, 2.03) | 0.409 | |
| SVS | IVW adjusted for atrial fibrillation | 0.93 (0.60, 1.44) | 0.734 |
| IVW adjusted for smoking | 0.78 (0.48, 1.28) | 0.324 | |
| IVW adjusted for BMI | 0.68 (0.39, 1.17) | 0.162 | |
| Fully adjusted model | 0.88 (0.49, 1.59) | 0.668 | |
| CES | IVW adjusted for atrial fibrillation | 1.26 (0.76, 2.11) | 0.371 |
| IVW adjusted for smoking | 1.53 (0.87, 2.66) | 0.137 | |
| IVW adjusted for BMI | 1.93 (1.14, 3.24) | 0.014 | |
| Fully adjusted model | 1.53 (0.84, 2.78) | 0.168 | |
| ICH | IVW adjusted for atrial fibrillation | 0.74 (0.27, 2.01) | 0.554 |
| IVW adjusted for smoking | 0.99 (0.40, 2.44) | 0.981 | |
| IVW adjusted for BMI | 1.10 (0.42, 2.85) | 0.852 | |
| Fully adjusted model | 0.73 (0.24, 2.23) | 0.576 |
Abbreviations: OR, odds ratio; CI, confidence interval; IVW, inverse variance-weighted; AS, any stroke; AIS, any ischemic stroke; LAS, large artery stroke; CES, cardioembolic stroke; SVS, small vessel stroke; ICH, intracerebral hemorrhage.