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. 2021 Jul 5;29(1):180–191. doi: 10.1093/eurjpc/zwab104

Figure 5.

Figure 5

Results of Cox regressions assessing the association between blood pressure phenotypes and incident cardiovascular disease amongst participants without prevalent cardiovascular disease at the third health check of the EPIC-Norfolk study. Model A—Univariable; Model B—Multivariable adjustment for age and ethnicity; Model C—Model B + body mass index, physical activity level, smoking and alcohol consumption; Model D—Model C + pre-existing co-morbidities (cardiovascular disease, diabetes mellitus, cancer, asthma, chronic obstructive pulmonary disease) and serum low-density lipoprotein cholesterol; Model E—Model D + antihypertensive treatment. SBP trajectories in men: Trajectory 1—borderline stable optimal SBP, Trajectory 2—rising normal/high normal SBP, Trajectory 3—rising grade 1 hypertension, Trajectory 4—grade 1 hypertension → high-normal SBP, Trajectory 5—grade 2 → grade 1 hypertension. SBP trajectories in women: Trajectory 1—stable optimal SBP, Trajectory 2—rising normal/high normal SBP, Trajectory 3—high-normal SBP → grade 1 hypertension, Trajectory 4—decreasing grade 1 hypertension, Trajectory 5—grade 1 → grade 2 hypertension. DBP trajectories: Trajectory 1—low optimal DBP, Trajectory 2—high optimal DBP, Trajectory 3—normal/high-normal DBP, Trajectory 4—grade 1 hypertension → normal DBP, Trajectory 5—stable grade 1/grade 2 hypertension. Median (interquartile range) follow-up was 9.4 (8.0–10.9) and 9.4 (7.8–11.0) years amongst men and women, respectively. DBP, diastolic blood pressure; SBP, systolic blood pressure.