Table 2. Effect of PI3K/Akt/mTOR inhibitors on GR function.

Compound	Major Targets	Gene activation by glucocorticoids	Gene inhibition by glucocorticoids
Rapamycin	mTORC1	Blunted (validated array)	Exaggerated (validated array)
OSI-027	mTORC1/2	N/A	N/A
Wortmannin	PI3K	Blunted	Exaggerated
LY-294002	PI3K	Blunted (validated array)	Exaggerated (validated array)
NVP-BEZ235	PI3K/mTOR	N/A	N/A
AZD8055	PI3K/mTOR	Blunted	Exaggerated
MK-2206	Akt1/2/3	N/A	N/A

HaCaT keratinocytes were pretreated with REDD1 inhibitors (1–10 uM) for hrs, and treated with FA (1 uM) for 6–24 hrs. The level of gene activation/repression was determined by Luciferase reporter assay. References: [137, 140]. Abbreviation: N/A: not assessed.