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. 2022 Feb 20;77:103888. doi: 10.1016/j.ebiom.2022.103888

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig 4 — IgG-S response in naïve vaccinees.

IgM-S (panel a) and IgG-S (panel b) measures in naïve vaccinees according to time of examination (T0, T1 and T2) and time of IgM-S positivity (IgM-S^NEG, n = 572, blue dots; IgM-S^POS_T1, n = 593, red dots; IgM-S^POS_T2, n = 418, purple dots). Being all naïve subjects, no individuals had detectable IgM-S at T0. Predicted means of ln(IgG-S) measures (with the 95% confidence interval) according to time of examination and time of IgM-S positivity (panel c) were obtained by a two-level linear regression model. Statistically significant p-values of the difference in the predicted means between consecutive times of examination at the same time of IgM-S positivity and between different times of IgM-S positivity at the same time of examination are reported in panel b. The horizontal lines indicate the cut-off value to discriminate positive and negative samples for each assay.