Table 3.
Pharmacokinetic Profiles of Case H after Native E.coli Asparaginase 10,000 IU/m2 Intramuscular Injection and Asparaginase-Specific Antibody Test
| Case profile | Case Hπ |
|---|---|
| AUC time range | 0 to 48 |
| Tmax (h) | 48 |
| Cmax (IU/mL) | 1.06 |
| Log AUC 0 to 48 (IU.h/mL) | 22.84 |
| post-48-hour activity | 1.06 |
| Asparaginase-specific antibody (ng/ml) | Positive* |
Abbreviation: AUC or Log AUC, area under the curve; Cmax, maximum concentration; Tmax, time-to-peak activity level; πThe pharmacokinetic graph was shown in Figure 2; *Asparaginase-specific antibody was 1.31 (ng/ml) (2.8 times of control). A value of more than 2.5 times of normal is considered positive. The mean level of another four volunteers (controlled cases) who did not have history of asparaginase administration was 0.48 ng/ml.