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. 2022 Jan 19;143(3):349–362. doi: 10.1007/s00401-021-02397-x

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2022

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Fig. 5 — Illustrative cases. Histological sections from representative participants. Case 1 is a female participant, (age-at-death is 89.2 years), with a tau-tangle burden within the 75th–100th percentile and severe arteriolosclerosis pathology in watershed brain regions. Case 2 is a female participant (age-at-death is 89.6 years), with a tau-tangle burden within the 25th percentile and mild arteriosclerosis pathology in watershed brain regions. Images represent H&E-stained sections of the posterior watershed brain regions (i and ii) and AT8-stained sections for PHF-tau-tangle pathology in the CA1 subregion of the mid-hippocampus (iii and vi), midfrontal gyrus (iv), and inferior parietal cortex (v)