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. Author manuscript; available in PMC: 2022 Feb 20.
Published in final edited form as: Nature. 2021 Oct 13;598(7882):646–651. doi: 10.1038/s41586-021-04013-0

Fig. 1. Endogenous MOPR activation in mNAcSh is necessary for potentiating state-dependent consummatory behavior.

Fig. 1.

a. Schematic of voluntary sucrose consumption assay. b. Microinjections of CTAP (blue) into mNAcSh reduced FD intake compared to vehicle (gray, n = 11). c. Oprm1 KO mice (blue) show full suppression of FD intake (n = 11 WT, 12 KO). d and e. Oprm1fl/fl x Penk-Cre+ mice (green) show suppressed FD intake compared to Cre− mice (gray, n = 13 Cre−, 11 Cre+). f. Retro MOPR deletion reduced FD intake compared to wildtype (gray, n = 13 wildtype, 12 local NAc, 11 retro-NAc). All error bars represent ± SEM and n = biologically independent mice or cells (e). Medians marked with orange bar. Post hoc p-values are derived from Two-way ANOVA with Sidak multiple comparisons (b, c, e, f, Extended Data Table 4).