Fig. 3.

Cntnap2^−/− mice exhibit altered levels of metabolites in the prefrontal cortex and hippocampus. a Cntnap2^−/− mice showed significantly lower level of Glu/GABA ratio in the prefrontal cortex than Cntnap2^+/+ mice. Two-tailed unpaired t-test with Welch’s correction, *P = 0.0111. b Cntnap2^−/− mice showed significantly lower level of total Creatine (Creatine + phospho − Creatine) in the prefrontal cortex. Two-tailed unpaired t-test with Welch’s correction, ***P = 0.0001. c Cntnap2^−/− mice showed significantly higher level of NAA/tCr ratio in the prefrontal cortex than Cntnap2^+/+ mice. Two-tailed unpaired t-test with Welch’s correction, *P = 0.0220. d Cntnap2^−/− mice showed a comparable level of PCr/tCr ratio in the prefrontal cortex to Cntnap2^+/+ mice. Two-tailed unpaired t-test with Welch’s correction, P = 0.8610. e Cntnap2^−/− mice showed a comparable level of Glx (Glutamine + Glutamate) in the prefrontal cortex. Two-tailed unpaired t-test with Welch’s correction, P = 0.7958. f Cntnap2^−/− mice showed a comparable level of GABA/Glu ratio in the hippocampus to Cntnap2^+/+ mice. Two-tailed unpaired t-test with Welch’s correction, P = 0.8243. g Cntnap2^−/− mice showed a comparable level of total Creatine in the hippocampus to Cntnap2^+/+ mice. Two-tailed unpaired t-test with Welch’s correction, P = 0.1994. h Cntnap2^−/− mice showed a comparable level of NAA/tCr in the hippocampus to Cntnap2^+/+ mice. Two-tailed unpaired t-test with Welch’s correction, P = 0.5117. i Cntnap2^−/− mice showed a comparable level of PCr/tCr in the hippocampus to Cntnap2^+/+ mice. Two-tailed unpaired t-test with Welch’s correction, P = 0.5854. j Cntnap2^−/− mice showed significantly higher level of Glx in the hippocampus to Cntnap2^+/+ mice. Two-tailed unpaired t-test with Welch’s correction, *P = 0.0478