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. 2022 Feb 20;12(2):e683. doi: 10.1002/ctm2.683

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© 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Clinical significance of human PRKAR2A‐derived circRNAs in ulcerative colitis (UC) and colitis‐associated cancer (CAC) patients. (A) The head‐to‐tail spicing structures of human PRKAR2A‐derived circRNAs were described. (B–D) The expressions of three PRKAR2A‐derived circRNAs in healthy controls, UC and CAC patients were determined by PCR analysis. (E–G) The bar plots showed the duration between the ulcerative colitis onset and time of surgery in CAC patients according to the circRNA levels. (H–J) Survival curves using the Kaplan‐Meier method compared the 5‐year overall survival (OS) rates (*p < .05)