TABLE 1.
Demographic characteristics of C‐BIOPRED
| Characteristic | Severe nonsmoking asthma (n = 342) | Smokers and ex‐smokers with severe asthma (n = 110) | Mild/moderate nonsmoking asthma (n = 93) | Healthy nonsmoking controls (n = 100) | p‐Value |
|---|---|---|---|---|---|
| Gender | |||||
| Male | 101 (29.5) | 106 (96.4) | 43 (46.2) | 36 (36.0) | <.001 |
| Female | 241 (70.5) | 4 (3.6) | 50 (53.8) | 64 (64.0) | |
| Age (years) | 53.39 ± 11.45 | 57.31 ± 9.46 | 48.65 ± 12.07 | 33.18 ± 14.20 | <.001 |
| Age of diagnosis (years) | 40.08 ± 16.42 | 44.46 ± 17.36 | 35.76 ± 16.07 | NA | <.001 |
| BMI (kg/m2) | 24.31 ± 3.65 | 25.05 ± 3.25 | 24.21 ± 3.08 | 22.38 ± 2.81 | <.001 |
| BMI Normal (< 28) | 293 (85.7) | 90 (81.8) | 84 (90.3) | 98 (98.0) | <.001 |
| BMI Obesity (> = 28) | 49 (14.3) | 20 (18.2) | 9 (9.7) | 2 (2.0) | |
| Smoking (Pack‐years) | NA | 28.71 (22.76) | NA | NA | NA |
| Current Smoker | NA | 44 (40.0) | NA | NA | NA |
| Ex‐smoker | NA | 66 (60.0) | NA | NA | NA |
| pre‐BD FVC, L | 2.57 ± 0.76 | 3.11 ± 0.80 | 3.35 ± 0.94 | 3.81 ± 0.97 | <.001 |
| pre‐BD FVC % pred, L | 83.43 ± 17.38 | 80.76 ± 16.54 | 97.21 ± 17.54 | 101.50 ± 12.35 | <.001 |
| pre‐BD FEV1, L | 1.55 ± 0.58 | 1.79 ± 0.71 | 2.21 ± 0.81 | 3.20 ± 0.79 | <.001 |
| pre‐BD FEV1% pred | 64.79 ± 21.16 | 60.87 ± 21.22 | 81.69 ± 23.13 | 106.01 ± 11.44 | <.001 |
| pre‐BD FEV1/FVC, % | 60.17 ± 12.29 | 56.72 ± 12.43 | 65.38 ± 11.65 | 84.19 ± 5.83 | <.001 |
| Post‐BD, n | 329 | 108 | 80 | ||
| Post‐BD FEV1, L | 1.82 ± 0.60 | 2.07 ± 0.72 | 2.45 ± 0.78 | NA | <.001 |
| Post‐BD FEV1% pred | 76.02 ± 21.16 | 70.47 ± 21.93 | 91.03 ± 21.79 | NA | <.001 |
| Post‐BD FEV1 (% increase) | 21.60 ± 15.45 | 17.88 ± 14.73 | 14.74±10.56 | NA | <.001 |
| Exacerbations in prior year | 1.50 ± 1.80 | 1.36 ± 1.60 | 0.33 ± 0.54 | NA | <.001 |
| Exacerbation in the previous year, n(%) | |||||
| Yes | 113 (33.0) | 36(32.7) | 64 (68.8) | NA | <.001 |
| No | 219 (64.0) | 72 (65.5) | 27 (29.0) | NA | |
| Healthcare resource utilization, n(%) | |||||
| Yes | 64 (18.7) | 14 (12.7) | 5 (5.4) | NA | <.001 |
| No | 278 (81.3) | 96 (87.3) | 88 (94.6) | 100 (100.0) | |
Abbreviations: BD, bronchodilator; BMI, body mass index; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; Max, maximum; Min, Minimum, N, number of subjects in the cohort, n, Number of subjects included in the analysis; NA, Not applicable; SD, Standard deviation.
Note: Data are shown as mean ± standard deviation, unless as n (%). The subject level data used for FVC, pre‐BD FEV1, pre‐BD FEV1% pred, pre‐BD FEV1/FVC ratio, % analysis follows the algorithm below: If baseline data are available, then baseline data are used. Otherwise, if screening data are available, then screening data are used.