FIGURE 1.

Workflow to analyze the synergistic effect of morphometric and molecular data on classifier performance. Eight hundred fifty‐three patient tissues were analyzed with MALDI mass spectrometry imaging (MSI), followed by hematoxylin & eosin staining and morphometric image analysis. Morphometric and molecular data of tumour regions were used both separately and in synergy to train three random forest classifiers. Patients were split into training and independent validation sets, followed by data normalization, feature selection and classifier training and validation