Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 2;102(1):379–410. doi: 10.1152/physrev.00043.2020

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Published by the American Physiological Society.

PMC Copyright notice

FIGURE 7. — Osteocytes generate a microenvironment supportive for the growth of cancer cells and exacerbated bone resorption. A: cocultures of osteocytes and myeloma-green fluorescent protein (GFP) cancer cells enable the study of communication by cell-to-cell direct cell contact and by the exchange of soluble factors. Under these conditions, myeloma cells establish physical contact with the body and dendritic processes of osteocytes. B: osteocytes transfected with nuclear GFP cocultured with myeloma cancer cells. Fragmented (yellow arrow) and normal (white arrow) nuclei in MLO-Y4 osteocytes cocultured with MM1.S myeloma cells are displayed. C: murine intratibial injection of myeloma cells engrafts and produces multiple myeloma (MM) tumors in the bone marrow tumors that induce osteolytic lesions (red arrows) similar to those seen in myeloma patients. D: pharmacological blockade of the osteocyte-derived factor Sclerostin with a neutralizing antibody (anti-Sclerostin Ab) prevents the progression of the myeloma-induced bone disease in mice bearing myeloma tumors. Three-dimensional micro-computed tomography (μCT) reconstructions of C57BL/KaLwRijHsd bones bearing 5TGM1 myeloma cells are shown.