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. 2022 Feb 21;38(10):110502. doi: 10.1016/j.celrep.2022.110502

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© 2022 The Author(s)

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In mice, BCG vaccination induces unspecific protection against IAV infection, but not against SARS-CoV-2

(A) Experimental model of BCG vaccination and intranasal (i.n.) IAV infection in C57BL/6J mice.

(B) Mortality (top) and morbidity (bottom) of 1-month BCG-i.v.-vaccinated or nonvaccinated control C57BL/6J mice after i.n. infection with a lethal dose of 90 plaque-forming units (PFU) influenza A/Puerto Rico/8/34 (IAV-PR8), n = 7–10/group.

(C) Lung viral load in BCG-i.v.-vaccinated and control nonvaccinated C57BL/6J mice at day 3 post sublethal IAV-PR8 infection (50 PFU), n = 13/group.

(D) Experimental model of BCG vaccination and i.n. or intratracheal (i.t.) SARS-CoV-2/SB2 infection in B6.Cg-Tg(K18-ACE2)2Prlmn/J mice.

(E) Mortality (top) and morbidity (bottom) (n = 8/group) of BCG-vaccinated and control K18-hACE2/J mice after i.n. infection with 1 × 10⁴ TCID50/mL SARS-CoV-2.

(F) Lung viral load at day 3 and day 5 post sublethal i.t. SARS-CoV-2/SB2 infection (4,000 TCID50/mL), n = 3–5/group.

Stars in morbidity curves (B and E) indicate significant weight loss compared with day 0. Data are displayed as mean ± SEM. ^∗p < 0.05, ^∗∗p ≤ 0.01, ^∗∗∗p ≤ 0.001, ^∗∗∗∗p ≤ 0.0001 (survival analyses and two-way ANOVA). See also Figure S1 and Table S1.