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. 2022 Feb 21;38(10):110502. doi: 10.1016/j.celrep.2022.110502

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© 2022 The Author(s)

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In Roborovski hamsters, BCG vaccination provides no protection against sublethal and lethal SARS-CoV-2 infection

(A) Experimental model of BCG vaccination and i.n. infection with SARS-CoV-2/RIM-1 in Roborovski hamsters.

(B and C) Mortality and morbidity of BCG-vaccinated and control Roborovski hamsters after i.n. infection with a sublethal (B) or lethal dose (C) of SARS-CoV-2/RIM-1, n = 7/group.

(D) Lung viral load in BCG-vaccinated and nonvaccinated Roborovski hamsters at day 3 post infection with a sublethal (low dose) or lethal dose (high dose) of SARS-CoV-2/RIM-1 as determined by TCID50/mL assay, n = 4–5/group.

Stars in morbidity curves (B and C) indicate significant weight loss compared with day 0. Data are displayed as mean ± SEM. ^∗p < 0.05, ^∗∗p ≤ 0.01, ^∗∗∗p ≤ 0.001, ^∗∗∗∗p ≤ 0.0001 (two-way ANOVA). See also Figure S3 and Table S1.