Table 1.
Current research foundations of pyroptosis and ovarian cancer.
| Year | Authors | Research object | Ovarian cancer cell lines | Gate molecules | Signaling pathways | Additional information |
|---|---|---|---|---|---|---|
| 2021 | Berkel et al. (100) | Differential expression and copy number variations of GSDMs | / | / | / | In epithelial ovarian cancer, the expression of GSDMB is increased in mucinous histotype compared to endometrioid and serous histotypes. Also, the expression of GSDMD is elevated in clear cell and serous histotypes compared to endometrioid histotype. |
| 2021 | Ye et al. (101) | Pyroptosis-related genes | / | / | / | The 13 downregulated genes include PRKACA, GSDMB, SCAF11, PJVK, CASP9, NOD1, PLCG1, NLRP1, GSDME, ELANE, TIRAP, CASP4, and GSDMD while the 18 upregulated genes are GPX4, NLRP7, NLRP2, CASP3, CASP6, TNF, IL1B, IL18, CASP8, NLRP6, GSDMA, GSDMC, PYCARD, CASP5, AIM2, NOD2, NLRC4, and NLRP3. |
| 2018 | Li et al. (102) | LncRNA GAS5 | SKOV3, OVCAR-3, A2780, and 3AO | GSDMD | The canonical pathway | Depletion of lncRNA GAS5 promotes viability of OVCA cells, while the overexpression of lncRNA GAS5 inhibits proliferation and colony formation in OVCA cells. |
| 2021 | Tan et al. (103) | LncRNA HOTTIP | CAOV-3, A2780, SKOV3, and OVCAR3 | GSDMD | ASK1/JNK signaling pathway | LncRNA HOTTIP is upregulated in ovarian cancer tissues, and microRNA-148a-3p was a downstream target gene of HOTTIP, exerting negative effects on the regulatory functions of HOTTIP. |
| 2020 | Liang et al. (104) | Osthole | A2780 and OVCAR3 | GSDME | / | Osthole could mediate GSDME-dependent pyroptosis while suppressing cell death by mitochondria-mediated apoptosis and causing cell autophagy in OVCA. |
| 2020 | Zhang et al. (105) | Nobiletin | A2780 and OVCAR3 | GSDMD, GSDME | / | Nobiletin could inhibit cell proliferation, induce apoptosis via DNA damage in a dose-dependent way, and mediate pyroptosis through induction of autophagy in OVCA cells. |
| 2019 | Qiao et al. (106) | α-NETA | Ho8910, Ho8910PM, Hey, SKOV3, and A2780 | GSDMD | GSDMD/caspase-4 pathway | α-NETA treatment causes epithelial ovarian cancer cell membrane blistering and cytoplasm leakage, typical manifestations of cells undergoing pyroptosis, which could be arrested by β-arrestin-2. |