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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Alcohol Clin Exp Res. 2021 Dec 29;46(2):221–231. doi: 10.1111/acer.14760

Figure 1: Extracellular vesicle associated miRNA (EV-miRNA) expression changes with heavy alcohol drinking.

Figure 1:

A) Experimental Design for the study. B,C) Volcano plots showing significant (FDR≤0.05) differentially expression miRNA with heavy drinking in female (B) and male (C) macaques. D) Venn diagram comparing DEmiRNA between male and female macaques with heavy drinking. E) Bubble plot depicting GO Biological processes associated with the validated target genes of the indicated upregulated EV-miRNA from males and females with heavy drinking. The size of the bubble represents the number of target genes, and the color represents the -log10(q-value) significance of enrichment.