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. 2022 Feb 20;79(3):140. doi: 10.1007/s00018-021-04123-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — MRI of GBM biopsies for each edema index (EI) category. In the first row a glioma with EI approximately = 1; in the second row a glioma with EI > 2; in the third row a glioma with 1 < EI < 2. In a, f, k T1 with gadolinium sequence. In b, g and l tumor volume was segmented in green. In c, h and m FLAIR sequences, co-registered with T1 with gadolinium. In d, i and n edema volume was segmented in yellow. In e, j and o tumor and edema volume segmentation is represented on a T1 with gadolinium acquisition