Table 3.
Clinical trials about radiosensitizers based on nanomaterials.
| NCT number | Title | Cancer type | Treatment | Phase | Recruitment Status |
|---|---|---|---|---|---|
| NCT04899908 | Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases | Brain Cancer Brain Metastases Melanoma Lung Cancer Breast Cancer Colorectal Cancer Gastrointestinal Cancer |
Radiation: Stereotactic Radiation Drug: AGuIX gadolinium-based nanoparticles Other: Placebo |
Phase 2 | Not yet recruiting |
| NCT03818386 | Radiotherapy of Multiple Brain Metastases Using AGuIX® (NANORAD2) | Brain Metastases | Drug: AGuIX®
Radiation: Whole Brain Radiation Therapy |
Phase 2 | Recruiting |
| NCT04094077 | Evaluating AGuIX® Nanoparticles in Combination With Stereotactic Radiation for Brain Metastases (NANOSTEREO) | Brain Metastases | Drug: AGuIX | Phase 2 | Terminated |
| NCT04784221 | Reirradiation by Nanoparticles and Hypofractionated Protontherapy of Relapsed Tumors: Non-randomized Phase II Study. (NANOPRO) | Recurrent Cancer | Radiation: Radiation by protontherapy associated to nanoparticles injection | Phase 2 | Not yet recruiting |
| NCT04789486 | Nano-SMART: Nanoparticles With MR Guided SBRT in NSCLC and Pancreatic Cancer | Lung Cancer Pancreatic Adenocarcinoma |
Drug: AGuIX Radiation: Radiotherapy |
Phase 1 Phase 2 |
Recruiting |
| NCT02820454 | Radiosensitization of Multiple Brain Metastases Using AGuIX Gadolinium Based Nanoparticles | Brain Metastases | Drug: AGuIX Radiation: whole brain radiation therapy |
Phase 1 | Completed |
| NCT02721056 | NBTXR3 Crystalline Nanoparticles and Stereotactic Body Radiation Therapy in the Treatment of Liver Cancers | Liver Cancer | Radiation: NBTXR3, IL or IA injection + SBRT | Phase 1 Phase 2 |
Terminated |
| NCT04240639 | An Extension Study MRI/US Fusion Imaging and Biopsy in Combination With Nanoparticle Directed Focal Therapy for Ablation of Prostate Tissue | Neoplasms of the Prostate | Device: AuroShell particle infusion | Not Applicable | Recruiting |
| NCT02379845 | NBTXR3 Crystalline Nanoparticles and Radiation Therapy in Treating Randomized Patients in Two Arms With Soft Tissue Sarcoma of the Extremity and Trunk Wall | Adult Soft Tissue Sarcoma | Device: NBTXR3 Device: Radiation therapy |
Phase 2 Phase 3 |
Completed |
| NCT01433068 | NBTXR3 Crystalline Nanoparticles and Radiation Therapy in Treating Patients With Soft Tissue Sarcoma of the Extremity | Adult Soft Tissue Sarcoma | Device: NBTXR3 | Phase 1 | Completed |
| NCT04484909 | NBTXR3 Activated by Radiation Therapy for the Treatment of Locally Advanced or Borderline-Resectable Pancreatic Cancer | Pancreatic Adenocarcinoma | Other: Hafnium Oxide-containing Nanoparticles NBTXR3 Radiation: Radiation Therapy |
Phase 1 | Recruiting |
| NCT02680535 | MRI/US Fusion Imaging and Biopsy in Combination With Nanoparticle Directed Focal Therapy for Ablation of Prostate Tissue | Neoplasms of the Prostate | Device: AuroShell particle infusion | Not Applicable | Not Applicable |
| NCT04505267 | NBTXR3 and Radiation Therapy for the Treatment of Inoperable Recurrent Non-small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | Other: Hafnium Oxide-containing Nanoparticles NBTXR3 Radiation: Radiation Therapy |
Phase 1 | Recruiting |
| NCT02033447 | Magnetic Nanoparticle Thermoablation-Retention and Maintenance in the Prostate:A Phase 0 Study in Men (MAGNABLATE I) | Prostate Cancer | Other: Magnetic Nanoparticle Injection | Early Phase 1 | Completed |
| NCT04862455 | NBTXR3, Radiation Therapy, and Pembrolizumab for the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Cancer | Head and Neck Squamous Cell Carcinoma | Other: Hafnium Oxide-containing Nanoparticles NBTXR3 Radiation: Hypofractionated Radiation Therapy Biological: Pembrolizumab Radiation: Stereotactic Body Radiation Therapy |
Phase 2 | Recruiting |
| NCT04834349 | Re-irradiation With NBTXR3 in Combination With Pembrolizumab for the Treatment of Inoperable Locoregional Recurrent Head and Neck Squamous Cell Cancer | Head and Neck Squamous Cell Carcinoma | Other: Hafnium Oxide-containing Nanoparticles NBTXR3 Procedure: Intensity-Modulated Proton Therapy Radiation: Intensity-Modulated Radiation Therapy Biological: Pembrolizumab |
Phase 2 | Recruiting |