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. 2022 Feb 7;13:810317. doi: 10.3389/fimmu.2022.810317

Figure 1.

Figure 1

The crosstalk of lncRNA-miRNA-mRNA in RA. FLS, Fibroblast−like synoviocytes; PVT1, plasmacytoma variant translocation 1; SCUBE2, signal peptide-CUB-EGF-like containing protein 2; IL-1β, interleukin-1β; IL-6, interleukin-6; THBS2, thrombospondin-2; GAS5, growth arrest-specific transcript 5; HDAC4, histone deacetylase 4;PIAS3, protein inhibitor of activated STAT3; NEAT1, nuclear paraspeckle assembly transcript 1; MAPK1, mitogen-activated protein kinase 1; YY1, yin yang-1; mdm2, mouse double minute 2; Sirt6, sirtuin 6; PON1, paraoxonase 1; PBMC, peripheral blood mononuclear cell; NEAT1, nuclear paraspeckle assembly transcript 1; MDM2, murine double minute-2; SIRT6, sirtuin 6; MMP-15, matrix metalloproteinase-15; TLR4, toll-like-receptor 4; STAT3, signal transducer and activator of transcription 3.